Microbiome engineering
My research aims to establish fundamental principles for the precise control of microbiome composition and function. By designing targeted interventions that operate at multiple biological levels, I integrate genetic engineering of microorganisms, small-molecule interventions, dietary strategies, and the use of prebiotics and probiotics to shape microbial ecosystems in targeted ways. This work advances both our fundamental understanding of microbial dynamics and their application in translational medicine, with a particular focus on novel therapeutic strategies for metabolic disorders, cancer, and the gut-brain axis.
Synthetic Biology
My research in this area integrates gene editing technologies, including CRISPR-Cas systems, alongside computational modeling, automation, and high-throughput screening strategies to accelerate biological designs. I engineer modular, predictable genetic systems that enable microbial cells to execute complex functions, such as the biosynthesis of high-value bio-based materials, real-time environmental sensing, and precision optimization of metabolic pathways for applications in biotechnology and medicine.
Fermented Foods
My research as part of Healthferm aims to bridge fundamental microbiome science with real-world applications in health and sustainable food systems. As part of this european project I investigate the connection between microbiomes, food and human health, with a particular emphasis on plant-based fermented foods and their impact on gut microbiota. By integrating microbiology, food science, and systems biology, my work elucidates how beneficial microbes enhance food quality, modulate gut microbial ecosystems, and contribute to sustainable nutrition. I explore the microbial diversity of both traditional and novel fermented foods, uncover the mechanisms through which they confer health benefits, and examine the broader implications of dietary interventions on gut microbiota composition and metabolic function.
Promoting collaborative research networks and science dissemination
My work in this area focuses on two levels. First, I am committed to engage the broader public with science and its potential for positive impact. I believe that the impact of scientific research extends far beyond the laboratory, and I actively seek to communicate this through accessible platforms such as podcasts, videos, and articles aimed at the general public (find more in Media). By doing so, I aim to foster an awareness of the possibilities for positive impact within scientific research and inspire others to recognize its value in addressing global challenges.
Second, I am dedicated to create scientific communities, fostering collaborative environments that enable knowledge transfer, and creating career opportunities for emerging researchers. I actively mentor students and early-career scientists, while also organizing educational initiatives, courses, and conferences to promote interdisciplinary dialogue and sharing of experience and ideas.
Ruben Vazquez-Uribe 